Principal Investigator

Sidong Huang

Sidong Huang, Ph.D. 

Dr. Sidong Huang is an Associate Professor in the Department of Biochemistry at McGill University. He holds a Canada Research Chair in Functional Genomics and is a Member of the Rosalind and Morris Goodman Cancer Research Centre. He is also an Associated Member of the McGill University Research Centre on Complex Traits and is the scientific director of the Genetic Perturbation Service at McGill University.

He studied Biochemistry and Molecular Biology at Boston University and subsequently obtained his PhD from the University of California, San Francisco in 2003, under the supervision of Dr. Erin O’Shea. He then joined the laboratory of Dr. Rene Bernards at the Netherlands Cancer Institute for his postdoctoral training. In 2013, he was appointed as an Assistant Professor at McGill University. His work has uncovered novel resistance mechanisms to cancer therapeutics, identified new treatment strategies and led to the establishment of clinical trials.

Lab Members


Geneviève Morin

Research Assistant

Geneviève obtained her Master’s Degree from University of Montreal in 2010 and joined the lab in 2015. She provides technical support to the team and manages the Genetic Perturbation Service. Her research focuses on the mechanisms of drug resistance in non-small cell lung cancer.


Jutta Steinberger

Research Associate

Jutta obtained her PhD’s Degree from the Medical University of Vienna in 2014 and recently joined the lab in 2019. She helps manage projects in the lab and leads a new project focusing on DICER1-associated sarcomas.


Xianbing Zhu

PhD Candidate

Xianbing joined the lab in 2017. His main research focus is to uncover resistance mechanisms to CDK4/6 inhibitors and to develop novel effective treatment strategies to enhance the clinical utility of these FDA-approved anticancer drugs.


Zheng Fu

PhD Candidate

Zheng joined the lab in 2017. He works on revealing the driver pathways of SMARCA4-loss and targeting vulnerabilities in SMARCA4-deficient ovarian and lung cancers.


Giulio Aceto

MSc Candidate

Giulio joined the lab in 2019. His research aims to uncover the driver pathways of SWI/SNF-deficient rhahdoid tumors using functional genetics approaches.


Laure Poittevin De La Frégonnière

MSc Candidate

Laure joined the lab in 2019. Her research focuses on cell cycle feedback regulation in response to CDK4/6 inhibition in cancer.


Howard Li

Undergraduate Student

Howard is an undergraduate student in the Department of Biochemistry at McGill University. He is studying resistance mechanisms to CDK4/6 inhibitors.

Connie Yang
Undergraduate Student

Connie is an undergraduate student in the Department of Anatomy and Cell Biology at McGill University. She works on chromatin factors modulating chemotherapy responses in cancers.

Bianca Adams
Undergraduate Student

Bianca is an undergraduate student in the Department of Biochemistry at McGill University. She is exploring novel strategies targeting common modes of drug resistance to CDK4/6 inhibitors.

Former Lab Members

Yibo Xue, PhD student (2014-2019), Now a Postdoctoral Fellow, University of Toronto, Toronto, Canada

Tim Kong, Honors Undergraduate Student, Master Student, Research Assistant (2015-2019) Now an MD/PhD student, Washington University in St. Louis, St. Louis, USA 

Rachel Bramley, Undergraduate Student (2018) Now a Dental Medicine student, University of Saskatchewan, Saskatchewan, Canada

Cameron Levins, Master Student (2016-2018) Now a Medical School student, McGill University, Montreal, Canada 

Jessica Karaguesian, Undergraduate Student (2017) Now an Undergraduate student, McGill University, Montreal, Canada 

Lashanda Skerritt, Summer Student (2017) Now an MD/PhD student, McGill University, Montreal, Canada 

Sara Ferwati, Master Student (2015-2017) Now an Epidemiologist at Government of Nunavut, Canada 

Nikki Cliffe, Summer Student, Honors Undergraduate Student (2016-2017) Now a Medical School Student, Royal College of Surgeons Ireland, Dublin, Ireland

Hongbo Chen, Visiting Professor (2015-2016) Now an Associate Professor, Sun Yat-sen University, China

Andreas Papadakis, Postdoctoral Fellow (2013-2016) Now a Research Associate at Lady Davis Institute, Montreal, Canada 

Kateryna Rossokhata, Honors Undergraduate Student (2016) Now an PhD student, McGill University Health Centre, Montreal, Canada 

Tiffany Cho, Summer Student (2015) Now a PhD Student, University of Toronto, Toronto, Canada 

Chi Ying Cheng, Postdoctoral Fellow (2013-2015) Now an Inside Sales representative at SCP Science, Baie-D’Urfe, Canada 

Larischa De Wet, Honors Undergraduate Student (2014) Now a PhD Student, University of Chicago, Chicago, USA

Zhi Zeng, Honors Undergraduate Student (2013-2014) Now a Research Associate, Exiger Vancouver, Vancouver, Canada

Meaghan Van Alstyne, Honors Undergraduate Student (2013) Now a PhD Student, Columbia University, New York, USA

Maryam Ghashghaei, Summer Student (2013) Now a PhD Student, McGill University, Montreal, Canada