Principal Investigator

Sidong Huang

Sidong Huang, Ph.D. 

Dr. Sidong Huang is an Associate Professor in the Department of Biochemistry at McGill University. He holds a Canada Research Chair in Functional Genomics and is a Member of the Rosalind and Morris Goodman Cancer Research Centre. He is also an Associated Member of the McGill University Research Centre on Complex Traits and is the scientific director of the Genetic Perturbation Service at McGill University.

He studied Biochemistry and Molecular Biology at Boston University and subsequently obtained his PhD from the University of California, San Francisco in 2003, under the supervision of Dr. Erin O’Shea. He then joined the laboratory of Dr. Rene Bernards at the Netherlands Cancer Institute for his postdoctoral training. In 2013, he was appointed as an Assistant Professor at McGill University. His work has uncovered novel resistance mechanisms to cancer therapeutics, identified new treatment strategies and led to the establishment of clinical trials.

Lab Members


Geneviève Morin

Research Assistant

Geneviève obtained her Master’s Degree from University of Montreal in 2010 and joined the lab in 2015. She provides technical support to the team and manages the Genetic Perturbation Service. Her research focuses on the mechanisms of drug resistance in non-small cell lung cancer.


Tim Kong

Research Assistant

Tim has been with the lab since 2015, where he completed his undergraduate IHI project and Master’s Degree. His research focuses on identifying novel targets  in breast cancer that can be exploited therapeutically to enhance current cancer immunotherapies.


Yibo Xue

PhD Candidate

Yibo joined the lab in 2014. He is uncovering druggable vulnerabilities and driver signalling in SWI/SNF-deficient cancers using complementary functional genetic screening tools. He is also learning to apply computational approaches to cancer research through a Master’s program at Georgia Institute of Technology.


Xianbing Zhu

PhD Candidate

Xianbing joined the lab in 2017. His main research focus is to uncover resistance mechanisms to CDK4/6 inhibitors and to develop novel effective treatment strategies to enhance the clinical utility of these FDA-approved anticancer drugs.


Zheng Fu

PhD Candidate

Zheng joined the lab in 2017. He works on revealing the driver pathways of SMARCA4-loss and targeting vulnerabilities in SMARCA4-deficient ovarian and lung cancers.


Giulio Aceto

MSc Candidate

Giulio joined the lab in 2019. His research aims to uncover the driver pathways of SWI/SNF-deficient rhahdoid tumors using functional genetics approaches.


Howard Li

Undergraduate Student

Howard is an undergraduate student in the Department of Biochemistry at McGill University. He is studying resistance mechanisms to CDK4/6 inhibitors.

Connie Yang
Undergraduate Student

Connie is an undergraduate student in the Department of Anatomy and Cell Biology at McGill University. She works on chromatin factors modulating chemotherapy responses in cancers.

Bianca Adams
Undergraduate Student

Bianca is an undergraduate student in the Department of Biochemistry at McGill University. She is exploring novel strategies targeting common modes of drug resistance to CDK4/6 inhibitors.