Publications


Selected Publications


Xue Y, Meehan B, Fu Z, Wang XQD, Fiset P, Rieker R, levins C, Kong T, Zhu X, Morin G, Skerritt L, Esther H, Venneti S, Martinez D, Jung S, Gonzalez AV, Guiot MC, Lockwood W, Spicer J, Agaimy A, Pastor W, Dostie J, Rak J, Foulkes WD, Huang S. SMARCA4 loss is synthetic lethal with CDK4/6 inhibition in non-small cell lung cancerNat Commun 2019 Feb 4; doi:10.1038/s41467-019-08380-1.

Xue Y, Meehan B, Macdonald E, Venneti S, Wang XQD, Witkowski L, Kong T, Martinez D, Morin G, Abedini A, Johson R, Cencic R, Chen H, Jelinic P, Papadakis AI, Auguste A, de Rink I, Kerkhoven R, Bertos N, Gotlieb W, Clarke BA, Leary A, Guiot MC, Pelletier J, Dostie J, Park M, Levine DA, Judkins A, Hass R, Rak J, Vanderhyden B, Foulkes WD, Huang S. CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in small cell carcinoma of the ovary, hypercalcemic typeNat Commun 2019 Feb 4; doi:10.1038/s41467-018-06958-9.

Papadakis AI*, Sun C*, Knijnenburg TA, Grernrum W, Hölzel M, Nijkamp W, Wessels LFA, Beijersbergen RL, Bernards R, Huang S SMARCE1 suppresses EGFR expression and controls responses to MET and ALK inhibitors in lung cancer. Cell Res 2015 April 25; doi: 10.1038/cr.2015.16. *Equal contribution

Sun C*, Wang L*, Huang S*, Heynen GJJE, Prahallad A, Robert C, Haanen J, Blank C, Wesseling J, Willems SM, Zecchin D, Hobor S, Bajpe PK, Lieftink C, Mateus C, Vagner S, Grernrum W, Hofland I, Schlicker A, Wessels L, Beijersbergen RL, Bardelli A, Di Nicolantonio F, Eggermont AMM, Bernards R. Reversible and adaptive resistance to BRAF(V600E) inhibition in melanomaNature 2014 Apr 3;508(7494). *Equal contribution

Huang S, Hölzel M, Knijnenburg T, Schlicker A, Roepman P, McDermott U, Garnett M, Grernrum W, Sun C, Prahallad A, Groenendijk F, Mittempergher S, Nijkamp W, Neefjes J, Salazar R, ten Dijke P, Uramoto H, Tanaka F, Beijersbergen RL, Wessels L, Bernards R. MED12 Controls the Response to Multiple Targeted Cancer Drugs Through Direct Regulation of TGFβ Receptor SignallingCell 2012 Nov; 151(5):937-50.

 Prahallad A*, Sun C*, Huang S*, Di Nicolantonio F*, Salazar R, Zecchin D, Beijersbergen RL, Bardelli A Bernards R. Unresponsiveness of Colon Cancer to BRAFV600E Inhibition Through Feedback Activation of EGFRNature 2012 Jan; 483(7387): 100-3. *Equal contribution

 Hölzel M*, Huang S*, Koster J, Øra I, Lakeman A, Caron H, Nijkamp W, Xie J, Callens T, Asgharzadeh S, Seeger RC, Messiaen L, Versteeg R, Bernards R. NF1 is a Tumor Suppressor in Neuroblastoma that Determines Retinoic Acid Response and Disease OutcomeCell 2010 Jul; 142(2): 218-229. *Equal contribution

Huang S, Laoukili J, Epping MT, Koster J, Hölzel M, Westerman BA, Nijkamp W, Hata A, Asgharzadeh S, Seeger RC, Versteeg R, Beijersbergen RL, Bernards R. ZNF423 is Critically Required for Retinoic Acid-induced Differentiation and is a Marker of Neuroblastoma Outcome Cancer Cell 2009 Apr; 15(4): 328-40.

Publications


Kong T, Xue Y, Cencic R, Monast A, Fu Z, Zhu X, Guiot MC, Foulkes WD, Park M, Pelletier J, Huang S. eIF4A inhibitors target feedback response and acquired resistance to CDK4/6 inhibitionMol Cancer Ther 2019 Aug 8. pii: molcanther.0162.2019. doi: 10.1158/1535-7163.MCT-19-0162.

Shorstova T, Marques M, Su J, Johnston J, Kleinmana C, Hamel N, Huang S, Alaoui-Jamalia MA, Foulkes WD, Witcher M. SWI/SNF-compromised cancers are susceptible to bromodomain inhibitorsCancer Res 2019 Mar 15;pii: 0008-5472.CAN-18-1545. doi: 10.1158/0008-5472.CAN-18-1545.

Xue Y, Meehan B, Fu Z, Wang XQD, Fiset P, Rieker R, levins C, Kong T, Zhu X, Morin G, Skerritt L, Esther H, Venneti S, Martinez D, Jung S, Gonzalez AV, Guiot MC, Lockwood W, Spicer J, Agaimy A, Pastor W, Dostie J, Rak J, Foulkes WD, Huang S. SMARCA4 loss is synthetic lethal with CDK4/6 inhibition in non-small cell lung cancerNat Commun 2019 Feb 4; doi:10.1038/s41467-019-08380-1.

Xue Y, Meehan B, Macdonald E, Venneti S, Wang XQD, Witkowski L, Kong T, Martinez D, Morin G, Abedini A, Johson R, Cencic R, Chen H, Jelinic P, Papadakis AI, Auguste A, de Rink I, Kerkhoven R, Bertos N, Gotlieb W, Clarke BA, Leary A, Guiot MC, Pelletier J, Dostie J, Park M, Levine DA, Judkins A, Hass R, Rak J, Vanderhyden B, Foulkes WD, Huang S. CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in small cell carcinoma of the ovary, hypercalcemic typeNat Commun 2019 Feb 4; doi:10.1038/s41467-018-06958-9.

Karimzadeh M, Jandaghi P, Papadakis AI, Trainor S, Rung J, Gonzàlez-Porta M, Scelo G, Vasudev NS, Brazma A, Huang S, Banks RE, Lathrop M, Najafabadi HS, Riazalhosseini Y. Aberration hubs in protein interaction networks highlight actionable targets in cancer. Oncotarget. 2018 May 18;9(38):25166-25180. doi: 10.18632/oncotarget.25382. eCollection 2018 May 18. PubMed PMID: 29861861; PubMed Central PMCID: PMC5982744.

Perron G, Jandaghi P, Solanki S, Safisamghabadi M, Storoz C, Karimzadeh M, Papadakis AI, Arseneault M, Scelo G, Banks RE, Tost J, Lathrop M, Tanguay S,
Brazma A, Huang S, Brimo F, Najafabadi HS, Riazalhosseini Y. A General  Framework for Interrogation of mRNA Stability Programs Identifies RNA-Binding Proteins that Govern Cancer Transcriptomes. Cell Rep. 2018 May 8;23(6):1639-1650. doi: 10.1016/j.celrep.2018.04.031. PubMed PMID: 29742422.

Robert F, Huang S, Pelletier J. CRISPR/Cas9 Editing to Facilitate and Expand Drug Discovery. Curr Gene Ther. 2017;17(4):275-285. doi: 10.2174/1566523217666171121164615. PubMed PMID: 29173168.

Zhan Y, Guo J, Yang W, Goncalves C, Rzymski T, Dreas A, Żyłkiewicz E, Mikulski M, Brzózka K, Golas A, Kong Y, Ma M, Huang F, Huor B, Guo Q, da Silva SD, Torres J, Cai Y, Topisirovic I, Su J, Bijian K, Alaoui-Jamali MA, Huang S, Journe F, Ghanem GE, Miller WH Jr, Del Rincón SV. MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanoma. J Clin Invest. 2017 Nov 1;127(11):4179-4192. doi: 10.1172/JCI91258. Epub 2017 Oct 16. PubMed PMID: 29035277; PubMed Central PMCID: PMC5663367.

Jandaghi P, Najafabadi HS*, Bauer AS*, Papadakis AI*, Fassan M, Hall A, Monast A, von Knebel Doeberitz M, Neoptolemos JP, Costello E, Greenhalf W, Scarpa A, Sipos B, Auld D, Lathrop M, Park M, Büchler MW, Strobel O, Hackert T, Giese NA, Zogopoulos G, Sangwan V, Huang S, Riazalhosseini Y, Hoheisel JD. Expression of DRD2 Is Increased in Human Pancreatic Ductal Adenocarcinoma and Inhibitors Slow Tumor Growth in Mice. Gastroenterology. 2016 Dec;151(6):1218-1231. doi: 10.1053/j.gastro.2016.08.040. Epub 2016 Aug 28. PubMed PMID: 27578530.*Equal contribution

Mui MZ, Zhou Y, Blanchette P, Chughtai N, Knight JF, Gruosso T, Papadakis AI, Huang S, Park M, Gingras AC, Branton PE. The Human Adenovirus Type 5 E4orf4 Protein Targets Two Phosphatase Regulators of the Hippo Signaling Pathway. J Virol. 2015 Sep;89(17):8855-70. doi: 10.1128/JVI.03710-14. Epub 2015 Jun 17. PubMed PMID: 26085163; PubMed Central PMCID: PMC4524087.

Andrei AZ, Hall A, Smith AL, Bascuñana C, Malina A, Connor A, Altinel-Omeroglu G, Huang S, Pelletier J, Huntsman D, Gallinger S, Omeroglu A, Metrakos P, Zogopoulos G. Increased in vitro and in vivo sensitivity of BRCA2-associated pancreatic cancer to the poly(ADP-ribose) polymerase-1/2 inhibitor BMN 673. Cancer Lett. 2015 Aug 1;364(1):8-16. doi: 10.1016/j.canlet.2015.04.003. Epub 2015 Apr 9. PubMed PMID: 25864590.

Papadakis AI*, Sun C*, Knijnenburg TA, Xue Y, Grernrum W, Hölzel M, Nijkamp W, Wessels LF, Beijersbergen RL, Bernards R, Huang S. SMARCE1 suppresses EGFR expression and controls responses to MET and ALK inhibitors in lung cancer. Cell Res. 2015 Apr;25(4):445-58. doi: 10.1038/cr.2015.16. Epub 2015 Feb 6. PubMed PMID: 25656847; PubMed Central PMCID: PMC4387553.*Equal contribution

Rajesh K, Krishnamoorthy J, Kazimierczak U, Tenkerian C, Papadakis AI, Wang S, Huang S, Koromilas AE. Phosphorylation of the translation initiation factor eIF2α at serine 51 determines the cell fate decisions of Akt in response to oxidative stress. Cell Death Dis. 2015 Jan 15;6:e1591. doi: 10.1038/cddis.2014.554. PubMed  PMID: 25590801; PubMed Central PMCID: PMC4669752.

Drosten M, Sum EY, Lechuga CG, Simón-Carrasco L, Jacob HK, García-Medina R, Huang S, Beijersbergen RL, Bernards R, Barbacid M. Loss of p53 induces cell proliferation via Ras-independent activation of the Raf/Mek/Erk signaling pathway. Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):15155-60. doi: 10.1073/pnas.1417549111. Epub 2014 Oct 6. PubMed PMID: 25288756; PubMed Central PMCID: PMC4210339.

Lai AZ, Cory S, Zhao H, Gigoux M, Monast A, Guiot MC, Huang S, Tofigh A, Thompson C, Naujokas M, Marcus VA, Bertos N, Sehat B, Perera RM, Bell ES, Page BD, Gunning PT, Ferri LE, Hallett M, Park M. Dynamic reprogramming of signaling upon met inhibition reveals a mechanism of drug resistance in gastric cancer. Sci Signal. 2014 Apr 22;7(322):ra38. doi: 10.1126/scisignal.2004839. PubMed PMID: 24757178.

Sun C, Hobor S, Bertotti A, Zecchin D, Huang S, Galimi F, Cottino F, Prahallad A, Grernrum W, Tzani A, Schlicker A, Wessels LF, Smit EF, Thunnissen E, Halonen P, Lieftink C, Beijersbergen RL, Di Nicolantonio F, Bardelli A, Trusolino L, Bernards R. Intrinsic resistance to MEK inhibition in KRAS mutant lung and colon cancer through transcriptional induction of ERBB3. Cell Rep. 2014 Apr 10;7(1):86-93. doi: 10.1016/j.celrep.2014.02.045. Epub 2014 Mar 27. PubMed PMID: 24685132.

Sun C*, Wang L*, Huang S*, Heynen GJ, Prahallad A, Robert C, Haanen J, Blank C, Wesseling J, Willems SM, Zecchin D, Hobor S, Bajpe PK, Lieftink C, Mateus C, Vagner S, Grernrum W, Hofland I, Schlicker A, Wessels LF, Beijersbergen RL, Bardelli A, Di Nicolantonio F, Eggermont AM, Bernards R. Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma. Nature. 2014 Apr 3;508(7494):118-22. doi: 10.1038/nature13121. Epub 2014 Mar 26. PubMed PMID:24670642. *Equal contribution

Walker JA, Gouzi JY, Long JB, Huang S, Maher RC, Xia H, Khalil K, Ray A, Van Vactor D, Bernards R, Bernards A. Genetic and functional studies implicate synaptic overgrowth and ring gland cAMP/PKA signaling defects in the Drosophila melanogaster neurofibromatosis-1 growth deficiency. PLoS Genet. 2013 Nov;9(11):e1003958. doi: 10.1371/journal.pgen.1003958. Epub 2013 Nov 21. PubMed PMID: 24278035; PubMed Central PMCID: PMC3836801.

Bajpe PK, Heynen GJ, Mittempergher L, Grernrum W, de Rink IA, Nijkamp W, Beijersbergen RL, Bernards R, Huang S. The corepressor CTBP2 is a coactivator of retinoic acid receptor/retinoid X receptor in retinoic acid signaling. Mol Cell Biol. 2013 Aug;33(16):3343-53. doi: 10.1128/MCB.01213-12. Epub 2013 Jun 17. PubMed PMID: 23775127; PubMed Central PMCID: PMC3753894.

Huang S, Hölzel M, Knijnenburg T, Schlicker A, Roepman P, McDermott U,
Garnett M, Grernrum W, Sun C, Prahallad A, Groenendijk FH, Mittempergher L, Nijkamp W, Neefjes J, Salazar R, Ten Dijke P, Uramoto H, Tanaka F, Beijersbergen RL, Wessels LF, Bernards R. MED12 controls the response to multiple cancer drugs through regulation of TGF-β receptor signalling. Cell. 2012 Nov 21;151(5):937-50. doi: 10.1016/j.cell.2012.10.035. PubMed PMID: 23178117; PubMed Central PMCID: PMC3672971.

Prahallad A*, Sun C*, Huang S*, Di Nicolantonio F*, Salazar R, Zecchin D, Beijersbergen RL, Bardelli A, Bernards R. Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR . Nature. 2012 Jan 26;483(7387):100-3. doi: 10.1038/nature10868. PubMed PMID: 22281684. *Equal contribution

Hölzel M*, Huang S*, Koster J, Ora I, Lakeman A, Caron H, Nijkamp W, Xie J, Callens T, Asgharzadeh S, Seeger RC, Messiaen L, Versteeg R, Bernards R. NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome. Cell. 2010 Jul 23;142(2):218-29. doi: 10.1016/j.cell.2010.06.004. PubMed PMID: 20655465; PubMed Central PMCID: PMC2913027. *Equal contribution

Huang S, Laoukili J, Epping MT, Koster J, Hölzel M, Westerman BA, Nijkamp W,  Hata A, Asgharzadeh S, Seeger RC, Versteeg R, Beijersbergen RL, Bernards R. ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome. Cancer Cell. 2009 Apr 7;15(4):328-40. doi: 10.1016/j.ccr.2009.02.023. PubMed PMID: 19345331; PubMed Central PMCID: PMC2693316.

Huang S, O’Shea EK. A systematic high-throughput screen of a yeast deletion collection for mutants defective in PHO5 regulation. Genetics. 2005 Apr;169(4):1859-71. Epub 2005 Feb 3. PubMed PMID: 15695358; PubMed Central PMCID: PMC1360160.

Huang S, Jeffery DA, Anthony MD, O’Shea EK. Functional analysis of the cyclin-dependent kinase inhibitor Pho81 identifies a novel inhibitory domain . Mol Cell Biol. 2001 Oct;21(19):6695-705. PubMed PMID: 11533256; PubMed Central PMCID: PMC99814.

Piffat KA, Hrdlicková R, Nehyba J, Ikeda T, Liss A, Huang S, Sif S, Gilmore TD, Bose HR Jr. The chicken RelB transcription factor has transactivation sequences and a tissue-specific expression pattern that are distinct from mammalian RelB. Mol Cell Biol Res Commun. 2001 Sep;4(5):266-75. PubMed PMID: 11529676.

Huang S, Scharf JM, Growney JD, Endrizzi MG, Dietrich WF. The mouse Naip gene cluster on Chromosome 13 encodes several distinct functional transcripts. Mamm Genome. 1999 Oct;10(10):1032-5. PubMed PMID: 10501978.

Endrizzi M, Huang S, Scharf JM, Kelter AR, Wirth B, Kunkel LM, Miller W, Dietrich WF. Comparative sequence analysis of the mouse and human Lgn1/SMA interval. Genomics. 1999 Sep 1;60(2):137-51. PubMed PMID: 10486205.

Scharf JM, Endrizzi MG, Wetter A, Huang S, Thompson TG, Zerres K, Dietrich WF, Wirth B, Kunkel LM. Identification of a candidate modifying gene for spinal muscular atrophy by comparative genomics. Nat Genet. 1998 Sep;20(1):83-6. PubMed PMID: 9731538.